Cause of Nickle Allergy Determined
The cause of such dermatitis was a mystery until recently when scientists in Germany have discovered the underlying mechanism of this reaction. Using mice, they figured out that nickel binds to a protein called toll-like receptor 4 or TLR4, which signals the immune system to initiate an inflammatory response.
Treatment of nickle allergy can be theoretically be made by creating a blocker to his protein.
Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. Nat Immunol. 2010 Aug 15. [Epub ahead of print]