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October 30, 2013

Cure for Noise-Induced Hearing Loss?

Normally, when mammals (including humans) are exposed to very loud sounds, permanent hearing loss may result due to cochlear hair cell injury. However, an experimental drug code-named LY411575 was found to regenerate new hair cells by suppressing a protein called Notch.

In essence, this drug restored hearing to mice deafened by loud noise.

Listen to an explanation by Harvard researcher Dr. Edge in this video.

However, human trials are a very long way off… so prevention is still the best way to avoid permanent noise-induced hearing loss. Wear hearing protection whenever loud sounds may be present!

Reference:
Notch Inhibition Induces Cochlear Hair Cell Regeneration and Recovery of Hearing after Acoustic Trauma. Neuron Volume 77, Issue 1, 58-69, 9 January 2013


Fauquier blog
Fauquier ENT

Dr. Christopher Chang is a private practice otolaryngology, head & neck surgeon specializing in the treatment of problems related to the ear, nose, and throat. Located in Warrenton, VA about 45 minutes west of Washington DC, he also provides inhalant allergy testing/treatment, hearing tests, and dispenses hearing aids. He is also the chief medical officer of O2Labz, a medical and scientific 3D animation company.Google+ Christopher Chang, MD Bio

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